I’m already using my Ledger Nano S as a cold storage stake address for my secure nodes. It’s not an ideally setup as LedgerHQ doesn’t recommend using the hardware wallet as a mining wallet due to lots of little payments also known as “dust payments”. This could cause issues. LedgerHQ already created a knowledge article about this: https://support.ledgerwallet.com/hc/en-us/articles/115005165209-Issues-with-BTC-mining
The idea is to group pending payments and let the Payment Master only needs to process 1 payout a week that clubs all pending payouts for each node. In that case, you only receive 1 payout each week = 52 transactions a year instead of 365 small transactions that could mess up the Ledger hardware wallet.